External Ca2+-Independent Release of Neurotransmitters
نویسندگان
چکیده
منابع مشابه
Release of Neurotransmitters
The synapse is the point of functional contact between one neuron and another. It is the primary place at which information is transmitted from neuron to neuron in the central nervous system or from neuron to target (gland or muscle) in the periphery. The simplest way for one cell to inform another of its activity is by direct electrical interaction, in which the current generated extracellular...
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The intracellular mechanisms regulating the process of evoked neurotransmitter release were studied in the cloned neurosecretory cell line PC12. Various agents were employed that were known, from previous studies in other systems, to stimulate release in a manner either strictly dependent or independent of the concentration of extracellular Ca2+, [Ca2+]o. Three parameters were investigated in c...
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There is no question about the fact that astrocytes and other glial cells release neurotransmitters that activate receptors on neurons, glia and vascular cells, and that calcium is an important second messenger regulating the release. This occurs in cell culture, tissue slice and in vivo. Negative results from informative experiments designed to test the mechanism of calcium-dependent neurotran...
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The mitochondrial membrane potential (DeltaPsi(m)) underlies many mitochondrial functions, including Ca(2+) influx into the mitochondria, which allows them to serve as buffers of intracellular Ca(2+). Spontaneous depolarizations of DeltaPsi(m), flickers, have been observed in isolated mitochondria and intact cells using the fluorescent cationic lipophile tetramethylrhodamine ethyl ester (TMRE),...
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We investigated how inhibition of mitochondrial Ca2+ uptake affects stimulation-induced increases in cytosolic [Ca2+] and phasic and asynchronous transmitter release in lizard motor terminals in 2 and 0.5 mM bath [Ca2+]. Lowering bath [Ca2+] reduced the rate of rise, but not the final amplitude, of the increase in mitochondrial [Ca2+] during 50-Hz stimulation. The amplitude of the stimulation-i...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 1992
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.1992.tb09736.x